Ka nts'etsopele ea aquaculture, lefu le bakoang ke likokoana-hloko tsa pathogenic le etsahala ka linako tse ling, tse senyang indasteri ea metsing.Ntle le ho ntlafatsa tsamaiso ea lisebelisoa, e bile taba ea bohlokoa ho felisa likokoana-hloko tsa pathogenic metsing a fepa le lisebelisoa.Ozone, kaha e na le oxidant e matla, e bolaeang likokoana-hloko ebile e sebelisoa haholo indastering, empa hape le ho thibela likokoana-hloko tsa metsi, ntlafatso ea boleng ba metsi le ho thibela likokoana-hloko tsa pat hogenic ka metsing le leqhubu le lefubelu.Microorganism ea pathogenic e ka thibeloa ka ho sebelisa tsamaiso ea ozone ho bolaea likokoana-hloko metsing le lisebelisoa tsa metsing.

Kaha ozone e na le ts'ebetso e phahameng ea ho bolaea likokoana-hloko, tlhoekiso ea metsi 'me e sa bake sehlahisoa se sa batleheng, ke sebolaea-mafu se loketseng bakeng sa temo ea metsing.Matsete a ho sebelisa sistimi ea ozone ho ikatisa ka metsing ha a phahame, 'me e boloka likokoana-hloko tse fapaneng, lithibela-mafu, ho fokotsa metsi a fapanyetsanoang, ho eketsa sekhahla sa ho pholoha ho fihlela bonyane makhetlo a mabeli, ho hlahisa lijo tse tala le tsa manyolo.Kahoo, ke moruo haholo.Hona joale, ho sebelisa ozone ho aquaculture ke ntho e tloaelehileng haholo Japane, Amerika le linaheng tsa Europe.