Ngokuthuthuka kwe-aquaculture, isifo esibangelwa i-pathogenic microorganism kwenzeka ngezikhathi ezithile, elimaza imboni yasemanzini.Ngaphandle kokuthuthukisa ukuphathwa kwezikhungo, kube yinto ebalulekile ukuqeda i-pathogenic microorganism emanzini okuphakelayo nezinsimbi.I-ozone, njengoba iyi-oxidant eqinile, isibulala-magciwane kanye ne-catalyst isetshenziswa kabanzi hhayi embonini kuphela, kodwa nasekubulaleni amagciwane emanzini, ekuthuthukisweni kwekhwalithi yamanzi kanye nokuvimbela i-pat hogenic microorganism emanzini nasemanzini abomvu.I-microorganism ye-pathogenic ingavinjelwa ngokusebenzisa uhlelo lwe-ozone ukukhipha amagciwane emanzini kanye nezinsiza.

Njengoba i-ozone isebenza kahle kakhulu ekubulaleni amagciwane, ekuhlanzeni amanzi futhi ingabangeli umkhiqizo ongafuneki, iyisibulala-magciwane esilungele i-aquaculture.Ukutshalwa kwezimali kokusebenzisa uhlelo lwe-ozone ekuzaleni kwe-aquaculture akuphakeme, futhi kusindisa izibulala-magciwane ezinhlobonhlobo, ama-antibiotics, kunciphisa amanzi ashintshiwe, kwandisa izinga lokuzalanisa libe okungenani izikhathi ezimbili, kukhiqiza ukudla okuluhlaza nokuphilayo.Ngakho-ke, kunomnotho impela.Njengamanje, ukusetshenziswa kwe-ozone kwezolimo zasemanzini kuyinto evamile eJapane, eMelika nasemazweni aseYurophu.